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References - Physical Causes of Stress
Stress occurs when the demands upon an individual surpass the resources in his/her arsenal to meet such demands. There are many causes for stress, which may be broadly classified into physical, mental, emotional, pe
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
rsonal, familial, social, professional, religious and spiritual.
Let us examine a few important physical causes of stress.
A. The Modern Life Style Stress: The modern life style is mainly responsi
Let us examine a few important physical causes of stress.
A. The Modern Life Style Stress: The modern life style is mainly responsi
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
le for the physical causes of stress.
- Sedentary life style stress: Lack of exercise predispose to many diseases like obesity, Diabet, problems associated with increased cholesterol etc. Toxic produ
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
cts of body metabolism accumulate in the body and the individual falls prey for a complex disorder called metabolic syndrome. This builds up stress with its associated effects on target organs. This becomes a viciou
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
cycle.
- Fast food culture: Fast food culture also predisposes the individual to obesity and the rich man's selective nutritional deficiencies. Most of these foods are allergenic due to in
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
reased content of artificial food additives.
- Excess consumption of alcohol, coffee, and cigarette. Though nutritionally worthless, these affect the body and mind in a number of harmful wa
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ys. Excess alcohol overburdens liver and the dependency state creates emotional distress in the individual and the family members. B. Exposure to chemicals in fertilizers, pesticides, a
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ditives and abuse of drugs, which slowly poisons the systems, are important causes of distress in modern life.
C. Competitiveness drives people to over exert themselves. It is common for athletes t
C. Competitiveness drives people to over exert themselves. It is common for athletes t
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
o push themselves beyond their body's endurance. Many physically unfit persons attempt vigorous exercises without proper warming up. Many individuals are workaholics and put in long hours of exertion at a stretch. S
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
me employees are made to work extra hours by greedy employers. All these deplete body's energy reserves and lead to exhaustion, ill-health and burn outs.
D. Ecological abuse exposes people to harmf
D. Ecological abuse exposes people to harmf
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
l radiation, toxic wastes, chemicals and impure air. These adversely affect the wellness of the individual and his surroundings. Protection of one's immediate environment becomes a personal priority and responsibili
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ty of each individual.
E. Lack of Good Health Habits: We tend to forget the essential requisites of good health (in addition to food and exercise) like fresh air, pure water and optimum sun exposur
E. Lack of Good Health Habits: We tend to forget the essential requisites of good health (in addition to food and exercise) like fresh air, pure water and optimum sun exposur
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
. Many people spend hours inside stuffy office rooms or ‘rest areas' filled with smoke. Daily intake of 8-10 glasses of water is essential for proper dispersal of nutrients throughout the body. Reduced water intake
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
causes dehydration which could lead to many symptoms like drowsiness, weakness, headache, loss of memory etc. Regular exposure to early morning or dawn sunlight will do wonders for our complexion and general health.
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
Denial of any of these basic health requirements for prolonged period of time will cause dis'ease' and, of course, distress.
F. Other Physical Illnesses: Any other physical illness is bound to caus
F. Other Physical Illnesses: Any other physical illness is bound to caus
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
stress in an individual, as health concerns are one of the foremost things that will affect the peace of mind of a person. Illness in other members of the family also produces varying amounts of stress and anxiety
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
in an individual.
G. Financial Stress: Falling in debt is highly stressful for any individual. Inflation, insufficient salary, lack of additional streams of income, improper saving habits, over exp
G. Financial Stress: Falling in debt is highly stressful for any individual. Inflation, insufficient salary, lack of additional streams of income, improper saving habits, over exp
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
nditure, failure in business all add to the financial worries of the individual.
H. Traffic Stress: Driving to and from the workplace is an immense gargantuan task in the metropolis and can contrib
H. Traffic Stress: Driving to and from the workplace is an immense gargantuan task in the metropolis and can contrib
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ute to the daily stress that an individual has to endure. Traffic snarls, impatience, abusive fellow drivers, traffic accidents, parking tickets etc are the contributors for the traffic stress. The sense of helpless
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
ess felt during the daily commuting can be overwhelming at times. The suppressed emotions can cause frustration, anger and depression if one does not learn how to handle this potentially threatening state of affairs
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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