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References - Health Implications of Chronic Stress
What is stress?
Stress can be defined as any type of change that causes physical, emotional or psychological strain.
Stress causes increased muscle tension which has a direct effect on increasing your pain levels. Therefore, reduction of stress and muscle tension helps
Stress can be defined as any type of change that causes physical, emotional or psychological strain.
Stress causes increased muscle tension which has a direct effect on increasing your pain levels. Therefore, reduction of stress and muscle tension helps
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
to reduce your pain. Stress saps your energy and reduces your ability to cope with the pain and your life.
Types of stress
Acute stress - a very short-term type of stress that can either be positive (like excitement at preparing for a deadline) or distressing (what we n
Types of stress
Acute stress - a very short-term type of stress that can either be positive (like excitement at preparing for a deadline) or distressing (what we n
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
rmally think of when we think of 'stress'); this is the type of stress we most often encounter in day-to-day life (e.g. flying, when you have a fear of it or having to make a presentation to colleagues when you are naturally shy.)
Chronic stress - the type of stress that
Chronic stress - the type of stress that
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
seems never-ending and inescapable, like the stress of a bad marriage, being a carer for a terminally ill parent or stress in the workplace, (coping with these types of stress can lead to burnout/ill effects on your health unless there is some stress management.)
Health
Health
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
implications of chronic stress
When faced with chronic stress, people begin to have physical symptoms. At first they can be relatively mild, like chronic headaches and frequent colds.
Later, however, more serious health problems may develop. Here are some stress-influen
When faced with chronic stress, people begin to have physical symptoms. At first they can be relatively mild, like chronic headaches and frequent colds.
Later, however, more serious health problems may develop. Here are some stress-influen
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ced conditions:
depression
diabetes
hair loss
heart disease
hyperthyroidism
obesity
obsessive-compulsive or anxiety disorder
sexual dysfunction
tooth and gum disease
ulcers
It has been estimated that as many
depression
diabetes
hair loss
heart disease
hyperthyroidism
obesity
obsessive-compulsive or anxiety disorder
sexual dysfunction
tooth and gum disease
ulcers
It has been estimated that as many
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
s 90% of doctor's visits are for symptoms that are at least partially stress-related!
'We play Calmtime every day at tea-time and what used to be a chaotic and stressful time is now calm and relaxed. And we enjoy the music.' Cynthia, Bristol
Chronic stress: how it affec
'We play Calmtime every day at tea-time and what used to be a chaotic and stressful time is now calm and relaxed. And we enjoy the music.' Cynthia, Bristol
Chronic stress: how it affec
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ts your body and how you can stay healthier
American and Canadian researchers conducting a huge study on the effects of stress on the immune system recently concluded that it all depended on the type of stress and how individuals responded to it. They examined 293 studie
American and Canadian researchers conducting a huge study on the effects of stress on the immune system recently concluded that it all depended on the type of stress and how individuals responded to it. They examined 293 studie
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
involving 19,000 people.
Chronic stress - the most damaging
The most damaging type of stress they found was chronic stress, caused, for example, by unemployment or caring for a relative with mental illness - both situations which have no end in sight. These have damagi
Chronic stress - the most damaging
The most damaging type of stress they found was chronic stress, caused, for example, by unemployment or caring for a relative with mental illness - both situations which have no end in sight. These have damagi
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
ng effects on the whole immune system. The key to it all, the researchers concluded, was whether the stress was never-ending or short-term. It was discovered that even the extreme stress of losing a partner was nowhere near as bad as chronic stress.
Chronic stress doesn'
Chronic stress doesn'
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
suit us as we get older
Another thing that was discovered, not surprisingly, is that the older we get the more susceptible we are to stress. Lawrence Whalley, Professor of Mental Health at Aberdeen University and author or 'The Ageing Brain' says: 'As we grow older -bet
Another thing that was discovered, not surprisingly, is that the older we get the more susceptible we are to stress. Lawrence Whalley, Professor of Mental Health at Aberdeen University and author or 'The Ageing Brain' says: 'As we grow older -bet
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
een about 45 and 55 - our stress responses become more exaggerated.'
He says that it's a fact, being prone to great anxiety in stressful situations increases with age. "All old people (50 plus) find stress very unpleasant: even the kind of stress a young person might fin
He says that it's a fact, being prone to great anxiety in stressful situations increases with age. "All old people (50 plus) find stress very unpleasant: even the kind of stress a young person might fin
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
d intoxicating."
Professor Stephen Palmer of City University in London and the Centre for Stress Management says: "I would say stress is always bad. A little bit of pressure can get you out of bed in the morning and give you focus. As you grow older there is more likely
Professor Stephen Palmer of City University in London and the Centre for Stress Management says: "I would say stress is always bad. A little bit of pressure can get you out of bed in the morning and give you focus. As you grow older there is more likely
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
o be long-term chronic stress (eg. caring for relatives, ill health etc.) - the very type that is bad for you."
'Whenever I feel strung out, like after a really pressurised day at work, I listen to Calmtime and that seems to put me into a much calmer and happier state fo
'Whenever I feel strung out, like after a really pressurised day at work, I listen to Calmtime and that seems to put me into a much calmer and happier state fo
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
r the remainder of that day.' David, Bristol
Help for stress related problems
"I haven't got time to relax!" the late Richard James
Though it may seem counterproductive to set aside time to relax in the midst of a busy lifestyle, doing so can actually help us to increa
Help for stress related problems
"I haven't got time to relax!" the late Richard James
Though it may seem counterproductive to set aside time to relax in the midst of a busy lifestyle, doing so can actually help us to increa
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
e our productivity, accomplish more in less time, and feel happier overall.
"Regular elicitation of the relaxation response has been scientifically proven to be an effective treatment for a wide range of stress related disorders." Prof. Herbert Benson MD
Research has in
"Regular elicitation of the relaxation response has been scientifically proven to be an effective treatment for a wide range of stress related disorders." Prof. Herbert Benson MD
Research has in
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
dicated that regularly relaxing can have a beneficial effect on a number of stress related health problems. In fact it can help any health problem that is caused or exacerbated by chronic stress.
Here are a few examples of health problems that can be helped by relaxation
Here are a few examples of health problems that can be helped by relaxation
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
include conditions:
gastrointestinal
Irritable Bowel Syndrome/Ulcers/Heart Burn
skin
Eczema/Psoriasis/Dermatitis/Urticaria/Acne
respiratory
Asthma/Emphysema/Chronic Obstructive Airways Disease
psychological
Anxiety/Stress/Depression/Panic attacks
gastrointestinal
Irritable Bowel Syndrome/Ulcers/Heart Burn
skin
Eczema/Psoriasis/Dermatitis/Urticaria/Acne
respiratory
Asthma/Emphysema/Chronic Obstructive Airways Disease
psychological
Anxiety/Stress/Depression/Panic attacks
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
immune
Rheumatoid Arthritis/Herpes Simplex/Colds and Flu
neurological
Multiple Sclerosis/Migraine/Epilepsy
reproductive
Infertility/Childbirth/Menopause/Premenstrual Syndrome
Endometriosis/Impotence
cardiovascular
Heart beat irregularities/High
Rheumatoid Arthritis/Herpes Simplex/Colds and Flu
neurological
Multiple Sclerosis/Migraine/Epilepsy
reproductive
Infertility/Childbirth/Menopause/Premenstrual Syndrome
Endometriosis/Impotence
cardiovascular
Heart beat irregularities/High
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
Blood Pressure/Heart Disease
Angina Pectoris/Raynaulds
musculoskeletal
Headaches/Arthritis/Back pain/Fibromyalgia
Muscular tension produces aches and pains, particularly in the neck and back.
endocrine
Diabetes Mellitus
general
Insomnia/Chronic Pai
Angina Pectoris/Raynaulds
musculoskeletal
Headaches/Arthritis/Back pain/Fibromyalgia
Muscular tension produces aches and pains, particularly in the neck and back.
endocrine
Diabetes Mellitus
general
Insomnia/Chronic Pai
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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