References - Recreation and Sports

There are about 150,000 of them spread throughout 213 countries and you need satellites to help you find them. What are they? Th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ey're geocaches and geocaching is a sport that is quickly gaining popularity.

The geocaches come in all different sizes and sha

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

es. Usually stored in a waterproof container, these caches are treasures of minimal value. The container is often a Tupperware c

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ontainer or ammo box. The "treasures" can be just about anything you can imagine: a mini--stapler; a toy soldier; foreign coins.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

How do you find them? That's the satellite part. If you haven't been in a cave for the last five years, you've probably heard o

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

f the Global Positioning System, or GPS. Just in case you're one of the cave people, GPS is a system of 24 satellites orbiting t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e earth at an altitude of 11,000 miles. A small handheld receiver, a little larger than a cell phone, picks up signals from the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

satellites and can pinpoint your position anywhere on earth, sometimes as accurately as 3 meters.

If you go to Geocaching.com y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

u can enter your location by ZIP Code, state, or country and get a list of caches in your area. Each listing has a log of who fo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

und the cache, when it was found, and usually what trinkets were taken and left.

You are given the coordinates of the cache in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

egrees of longitude and latitude. Enter those numbers in your GPS and start following that little handheld device. It may sound

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

easy, but depending on the individual cache, it can be a challenge.

Some examples of hiding places are in holes at the base of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

arge trees, holes in the face of a cliff, and some are even found in urban areas. One is under a bridge accessible only by rope.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Another clever place was created when a cable company worker attached an empty cable connection box to the side of a building.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

As you can imagine, public parks are popular places for hiding caches. However, they're not allowed in National Parks in the U.S

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. Geocachers, being outdoor sort of people, are mostly ecologically--minded, and there is even a "cache in trash out" program th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t promotes participants picking up trash that they may find while hunting treasure. Many places require permits for placing cach

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

es. Park authorities' main concern is damage to sensitive areas such as wetlands or locations of endangered flora or fauna.

GPS

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

receivers start at about $75.00 US and can be purchased at some department stores, sporting goods stores, or ordered online. Ama

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

zon.com often has very good prices. Geocaching really is a lot of fun and it's a great way to get outdoors and get some exercise

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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References - Geocaching -- The New High--Tech Sport

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