References - Recreation and Sports

As old favourites Skinner and Baddiel used to say on football’s finest ever TV show, ‘here’s a few things we noticed whilst watching football this week’. Well, in a similar vein

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

, I’ve noticed this; what on earth has happened to my favourite role in football? Having always had a passion for the beautiful game on the continent, I grew up looking forward

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

o James Richardson’s cheeky adjectives on a Saturday morning with Gazzetta Football Italia on Channel 4.

I took to Calico from the very start of the stations weekly broadcast (

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

mostly provoked by Paul Gascoigne’s move to Southern Europe), when Gazza’s new side Lazio lost in a 5-3 thriller to the then all conquering Milan on the opening day of the 1993/

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

4 Serie A season I was already hooked on this apparently ‘boring’ brand of football. Anyway, it soon became clear that Italian sides, and later I was to realise that this was th

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e case on much of the continent; all had a ‘number 10’. The first to capture my attention was the great Roberto Baggio, then of Juventus. The divine ponytail (as he was nickname

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

by fans) would drift in and out of the game, seemingly at his own whim, playing the game as if he was painting a picture.

It appeared that he was almost watching the game as a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n on field spectator, only ‘getting involved’ when he saw that the match required his presence, when it needed lifting to a higher level. As my footballing education developed I

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

discovered that Turin’s favourite son was not alone. Milan had Gullit, Sampdoria had Mancini. Further afield there was Gheorghe Hagi, Hristo Stoichkov, Ariel Ortega. Ludicrously

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

talented individuals who controlled the game, linking midfield and attack, both creating and scoring goals. They were the icons of their clubs and countries. And this trend con

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

inued throughout the nineties, until more recently something seems to have changed this.

Players that would previously given the freedom to wander the park are now put into mor

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e rigid formations, possibly to the extent that the idea of the ‘free role’ is almost deceased. Take Barcelona as a prime example. Ten years ago the string puller of the side wo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ld have been the great Ronaldinho. He would have slotted in wherever he saw fit and worked his magic as he saw fit. However, fast forward to today and you find the Brazilian out

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

on the left wing and the football being dictated from another source entirely.

Watching the Catalan giants over the past year or so and it has become clear that it is Deco tha

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

actually controls the tempo, masterminds the play, and where from? He sits deep in the midfield, virtually the same position as you will find an enforcer like Claude Makalele a

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t Chelsea. Ronaldinho may be the magic, but Deco is the brains.

If we go back to where we began in Italy, we visit Milan and see a similar trend. Although, like Barcelona, they

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

have a magician in the shape of Riccy Kaka’, they also have a conductor through Andrea Pirlo. Kaka’ has found himself employed wide right, left and as a centre forward as Ancell

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

otti attempts to bring a structure to the rossinieri. When dwelling on this idle musing it dawned on me that this has been in the water for sometime.

Zidane, the finest exponen

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

of the ‘Number 10’ since Maradona, was being more regularly employed by Real Madrid on the left flank, del Piero, the natural successor to Baggio, now on the left or ‘up top’.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

So does this mean that the hugely iconic role is something that will leave us, only to be replaced by a cunning holding midfielder such as Deco, Pirlo or Carrick on these shores

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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