References - Travel and Leisure

The third Ming emperor YongLe returned the capital to Beijing (from Nanjing) and in 1406 he began construction of a new and extremely grand imperial palace complex. The building work took 14

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

years to complete - and an estimated one million workers, including 100,000 artisans, were involved.

The Forbidden City gets its name from the fact that ordinary citizens were excluded from

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the complex. It is surrounded by a six meter deep, 52 meter wide moat. Inside the moat, the outer wall is 10 meters high and 3,400 meters long. The enormity of the complex, with the emperor h

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

idden inside, added to the imperial mystique and air of legitemacy.

The Forbidden City, located at the exact center of the ancient city of Beijing, was the home and seat of power of 24 emper

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ors during the mid to latter Ming and the Qing dynasties. By the end of the eighteenth century, some 9000 people were estimated to reside there. Apart from the royal family, these were eunuch

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s, concubines and maid-servants.

From Palace to Museum

The Forbidden City ceased being the political center of China in 1912 with the abdication of Pu Yi, the last emperor of China.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

PuYi wrote an interesting autobiography entitled 'From Emperor to Citizen'. The film 'The Last Emperor' was the first foreign film made in China and was partly filmed on location in the Forbi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

den City.

Today, the Forbidden City is a public museum, drawing the attention of millions of travellers and tourists from around the world. Here you can see and feel part of a place with ove

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r 600 years of history. Now renamed as the 'Palace Museum' ('GuGong' in chinese, meaning simply 'old palace'), its extensive grounds cover 720,000 square meters (74 hectares); it is nearly 1k

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

m from north to south. There are 800 buildings that have in total about 9,000 rooms.

The Forbidden City is listed by UNESCO as the largest collection of preserved ancient wooden structures i

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n the world, and was declared a World Heritage Site in 1987. It is a dazzling architectural masterpiece. The imperial palace grounds are located directly to the north of Tian'AnMen Square and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

are accessible from the square via Tian'AnMen Gate. Although no longer occupied by royalty, the Forbidden City remains a symbol of chinese sovereignty and the image of its entrance gate appe

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ars on the seal of the People's Republic of China.

Popular tourist destination

The Palace Museum is now one of the most popular tourist attractions in the world. Visitors can see the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

traditional palace architecture up close, enjoy the treasures of the imperial family and court, and learn of the legends and anecdotes about the imperial family and the court. White marble,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

alls of terra-cotta, roofs of glazed golden yellow tiles, and woodwork finished with paint, lacquer and gilding unite to create an effect of exceptional beauty (see http://www.ForbiddenCityCh

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ina.com" for many photos).

The chinese government has invested a lot of time and money in the Forbidden City and it is now a fantastic place to wander and dream of times gone by. Recently, t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

he site has been under a major renovation that has limited visitors to a few areas. However, it remains open and the great majority of places are still accessible.

The name Beijing translate

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s as 'northern capital' and is close to the old northern border of China protected by the Great Wall - about 40 km away. So with a trip to Beijing one can take in not only the Forbidden City

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

but also the Great Wall of China. Also, the world famous Summer Palace with its large man-made lakes (the country palace grounds of the emperor) is only 20 km to the west, near the popular Fr

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

agrant Hills. To the south is the equally famous, and beautiful, Temple of Heaven (TianTan). Beijing is close to the port city of Tianjin and therefore can be a stop on a cruise tour of China

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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