References - Travel and Leisure

Talk to most British citizens and you will soon find that many would gladly move overseas to live in paradise if you gave them just half a chance! Of course no one seems to actually act on this whim - but in this ar

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ticle we take a look at the top 3 reasons why there seems to be such an overwhelming desire to quit the U.K!

1) The weather! Yes, you guessed it, top of the list is the climate. Britons are famed for talking about,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and more appropriately, moaning about the weather. And they have every reason to moan!

The UK enjoys very little sunshine, lots of wind and rain, and for 60% of the year temperatures tend to be uncomfortably cold.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ritish winters are harsh, and lengthy. The fact that the UK is firmly in the Northern part of Europe also leads to very dark winters. "Seasonally adjusted disorder" (appropriately named SAD!) is a common disorder wh

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ch spreads depression among many British citizens for over half the year from September to March. Scientists have shown that it is caused by low light levels and short hours of daylight. Many people don't even know

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hat they suffer from it, they just presume that their depression is caused by other factors. Now on sale (at premium UK prices) are special fluorescent lights to assist people due to the fact that the UK doesn't get

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

much sunshine!

All of these explanations are of course of no consequence or consolation to UK citizens. Bad, unpredictable weather will always be a fact of life for people who choose to live in Britain and that is

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a fact! The ideal weather according to most Brits, is warm sunny days, no wind or rain, and a predictable climate that's not too hot but that never gets too cold. This ideal climate cannot be found in Britain and so

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the weather remains the top reason why many would emigrate!

2)High Taxes! Predictably, number two on the list is the unrelenting and almost ridiculous level of tax that British people must endure. Not content with

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

aking an arguably fair share of peoples' salary at source, the UK government seems very intent on getting British people to pay a lot more all over again in stealth taxes.

Petrol (gasoline) prices are an obvious ex

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

mple where stealth taxation has gone completely out of control. The typical price for a gallon of petrol in the UK is around ?4 (or US$7.20) It is the same petrol that U.S. citizens pay barely $2 a gallon for. Indee

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

d $2 is simply the price that it should be, but in Britain the Government sees it fit to add 200%+ of tax to this global base-price. There is no getting around this... if you buy petrol in the UK you must cough up t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

is very large amount of extra cash every time you fill up.

In addition, to illustrate the fact that British stealth taxes are hiked to the max, a growing number of Brits now travel to France or Holland just to buy

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

heir weekly groceries! All this energy and hassle to get around UK taxation, is it worth it? You bet it is... that's because the savings can by enormous due to the high levels of UK import duties on everything from

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

extiles to just a simple bottle of wine.

The only way to be free from these terrible burdens and escape these taxes forever, is to leave the UK for good!

3) Transport. Getting around this relatively small country

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s by all accounts, a nightmare. In fact you would have thought that the benefits of a small island (i.e. shorter distances and therefore less expensive building costs for roads and railways) would mean that transpor

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t would be of the highest quality. Not so. The UK fails almost completely. Public transport in the form of Rail and Bus services is expensive, of poor quality and makes the word "inconvenient" sound like the underst

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

tement of the century!

For those without a car, getting around really is a very frustrating and unpleasant day-to-day hassle. In suburbs and out of major cities, public transport services are virtually incompetentl

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

run, shutting down in the early evening and only giving sparse cover in less populated areas. It is not uncommon for people to abandon their travel plans altogether for fear of getting 'stranded' at their destinati

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n! Pensioners and single parents fair particularly badly.

Is it any wonder that the poor person waiting for 45 minutes at a bus stop in freezing wintry weather is dreaming of a life in paradise far away from the UK

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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References - Living Abroad: The Top 3 Reasons to Emigrate From The U.K. to an Overseas Paradise

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