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So many people are afraid to fly. Some believe this is due to the fear of falling. T

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

his fear is a real innate human fear - in fact when little babies are born there are

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

really no noticeable innate tendencies that they know. When baby horses are born th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ey instinctively know to get up and run. Dolphin babies start swimming with in minut

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s. Human babies as soon as they can see they are afraid of heights. It has been docu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

mented that if you put a baby on a glass table they are scared, so being afraid to f

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

all is innate.

So flying in a small airplane and being afraid to fly are definitely

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

real human fears, but they need not be and they are completely conquerable. If you

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

re afraid of flying, they there are many ways to get over this. Simply go take a fre

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e flying course out at your local airport. Most have introductory flights for around

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

$100.00 and they are really easy on first timers. Be sure to tell them of your fear

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s of flying and to be very careful your first time up.

Once you are airborne and ta

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

king to the flight instructor and understand a little more about how flying and airc

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

raft work you will see that flying is really nothing to be afraid of in fact it is v

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ery exhilarating to fly. Sometimes people get hooked on only one flight and sign up

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

for flying lessons thus they turn their fears into fun and a new skill. As a pilot m

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

self it is often hard to believe that anyone would be afraid to fly, until you think

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

about the little babies and their fears of falling and then you understand it is pe

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

rfectly natural to be afraid. But it is way more fun to conquer that fear than to le

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ave your feet on the ground and miss the beautiful view. Think on this; “clear prop!

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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