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I thought I would take some time to reflect on my first gold dredge and how it came to be mine. After years of looking around and going to every manufacturer out the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

re, it soon became apparent it was going to be a costly matter. Living in Southwestern PA, the dredge season is short and options on where to find gold are limited t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

o at least a 2 hour drive one way; so spending a few thousand dollars on a Gold Dredge was out of the question.

Why I needed the dredge was the first issu

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

. We all start out with the number 8 backhoe (that’s a shovel) a bucket to carry the material in and a gold pan. This all quickly escalates into more and more equipm

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ent. We are always looking for better quicker ways to do things. Like adding more classifiers and other toys.

The main reason was... I wanted one.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

/>So the dredge quest began. I ended up choosing eBay as my hunting ground. It became really clear that 90 percent of the people out there selling the equipment did

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

not really care about gold and wanted to just get rid of it. They could not answerer even simple questions about the gold dredge and could not be bothered with ship

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ping it. Driving to CA to pick it up was not on my to do list.

So after tracking 25 auctions and talking to the sellers, I hit pay dirt! I found

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

he most fantastic person in the world residing in Oregon. The gentleman answered all my questions, made special arrangements for shipping and unknown to me added som

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e bonuses to the shipment. He was getting out of the gold business for health reasons and wanted the dredge to go to someone who would appreciate it.

The

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

uction ended and I probably paid more for it because I wanted the dredge and wanted to help out a person I had only met through email. Payment sent and email exchang

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ed and I was like a kid at Christmas waiting for the mailman.

I happened to be out when the delivery came, I know this because I had to move the mountain

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

of boxes to get in the door. The only thing I was thinking at this point was, I will never get this thing back together again! I was wrong. The reason for a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

l the boxes was that every separate piece had its own custom made box with a wood frame and custom padding. I have never received any thing packed this good from any

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

manufacturer out there, and this was from a private seller!

So the unpacking began; there was a gold dredge, a fine gold separator, wet suits, gold pans

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nd anything else you could think of. The seller later told me he wanted everything to go to someone who could use it not sell it at his estate sale.

Then

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the biggest surprise of all was a laminated booklet showing step by step instructions -- complete with pictures -- of how to put the dredge together and how

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

to operate it. I have never dealt with some one willing to go the extra 100 miles like he did!

So that was my gold dredge buying experience, hope it ente

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tained you and helps restore your faith that there are fantastic people out there in the world. I still look at the manual he sent just to remind me! And as a surpri

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

se to him, he received a vial of the first PA glacial gold recovered with his former dredge sent to him the next season as a thank you for being a great person!

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Sally just happened to be there when the crime took place on Valentine's Day at her church. She had arrived at the couples' fellowship. She was early enough to find a good seat and wait for her husband Bill to arrive from his job...

New Flexible concrete building materials are making waves and could be the answer to increased safety and durability for Runways at Airports. Storms, severe weather and even Hurricanes can destroy runways and airports. These valuable infrastructures must remain intact to bring regions hit with such storms back to normalcy.

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References - Buying My First Gold Dredge - An Ebay Experience

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