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It is said that history repeats itself--A truism from fashion to auto design. It seems that what was once in vogue will eventually return to popularity. How many times have you heard someone say “Don’t throw that out, it will be ‘

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

in’ again in ten years.” Admit it most of you have a few choice items hanging in your closet, with the faint hope that the Dynasty or Miami Vice look will meander its way back into the mainstream.

We see the same trends in commerc

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ial and residential architecture and d?cor. Arched facades, tapestries, pillars and columns, are all reminiscent of styles that have repeated themselves from times of antiquity.

So what’s next? Perhaps we need look no further for

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

inspiration than, say, the 4th century BC—and the advent of mosaic art. When we hear the word mosaic, many of us think of small square tiles, often used in bathrooms and typically installed in monochromatic sheets. True mosaic art

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

couldn’t be more different.

Originally ancient artists formed their mosaics from water-smoothed pebbles, then from non-symmetrical pieces such as broken pottery and other scrap material. The mosaic would be a picture, perhaps a l

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ndscape, or mythological event. Churches throughout Europe incorporate intricate mosaics in their ceilings, walls, columns and floors depicting biblical events.

No one can say exactly when or precisely where the art of mosaic was

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

born, but there is evidence of this form regaining popularity throughout the ages by various civilizations. The Greeks developed the first school for mosaic artisans. Originally created to decorate floors, the Romans took the popu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

larity of the art to new heights using mosaics to decorate their walls. Archaeological evidence in Pompeii suggests that even common people would have simple mosaics adorning the walls of their homes. Over the centuries mosaics ha

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e experienced renewed popularity time and time again.

Far from little bathroom tiles, today’s incarnation of mosaics are the works of art so valued in previous ages. Intricate pictures and designs in motifs from ancient to contemp

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

orary genres, the mosaic can make a unique addition to almost any d?cor.

Dean Avey, owner of Artisan Mosaics in Toronto, Canada, points out that mosaic can find their way into almost every room of your home, as floor or wall coveri

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

gs. His gallery displays a wide variety of mosaics, in various sizes and shapes. “All made meticulously by hand,” boasts Avey. Artisan carries a wide range of mosaic sizes that can be used in small applications such as the centre

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

piece of a kitchen backsplash on up to mammoth mosaic carpets with the look and feel of an Oriental rug. Most of Artisan’s mosaics are made from tiny, hand-cut pieces of marble, in a variety of textures. According to Avey, tumbled

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

marble and slate mosaics are currently in vogue, as well as highly polished almost seamless patterns that are reminiscent of Italian wood inlay.

The practicality of ceramic tile, and its ever-increasing array of colour and texture

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

choices, makes it popular with home and business owners. The status of hardwood flooring, for its warmth and richness, is also at a peak. Setting mosaic medallions or ‘emblemata’ within your tiles or hardwood is certain to set you

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r choice of floor covering apart.

Mosaic carpets offer the rich beauty of a Persian rug in formal areas and foyers, with the practicality of stone for durability and ease of cleaning. The mosaic carpet has the added safety benefit

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of being set flush with the floor—particularly valuable in high traffic areas, and in spaces where accessibility is important.

Beautiful and practical, the mosaic is ideal for walls in kitchens and baths. No need for rooms that re

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

quire frequent clean-ups to look clinical or utilitarian. Mosaics will add warmth and charm to these spaces where typically little art is found. Outdoors mosaics can be used in swimming pools and fountains, or as the centrepiece o

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

f a porch or patio.

Commercial applications are limitless. Restaurants and hotels, business foyers, and elegant restrooms; all will welcome the air of distinction mosaic art can bring to their d?cor. “Custom insignias will be pop

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lar with businesses, clubs and institutions,” says Avey, whose company will custom order a mosaic of your crest, coat of arms, or business logo.

The revival of mosaics means authentic art will find its way into less conventional sp

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

aces, like floors and patios, bathrooms and kitchens, as well as in commercial applications; a welcome opportunity for professional decorators, home and business owners. So once again, it is in with the old, the really, really old

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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