References - Home Improvement

Trapped heat and moisture can raise energy costs, cause ice dams, and damage roof system components as well as structural and personal items located inside the attic w

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

here temperatures can easily reach 150° F (65° C). Condensation that forms inside attics can be caused by the use of washing machines, dish washers, bath tubs, showers

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

, and tumble driers unless these items are properly ventilated through the roof. In some cases the condensation can be bad enough to be mistaken for a roof leak.

Here

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

are some problems associated with an improperly ventilated attic space. Sumps between rafters (deck deflection) can happen because after awhile (sometimes several ye

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ars, sometimes only a couple years), a plywood roof deck can warp or deteriorate and become spongy and dangerous to walk on. This occurs because one side of plywood de

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

cking needs be able to "breathe" by being exposed to circulating air. The adhesives used in the plywood can deteriorate or Dry Rot can occur because of condensation.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ater vapor will condense first on anything metal inside the attic; this will eventually cause the metal to rust. Heads can rust off nails, metal plumbing straps or str

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

aps holding HVAC ducting can rust in two causing the ducting to crash down on top of the ceiling joists or through a suspended ceiling. This problem is more common in

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

humid climates.

In colder climates – generally where the average January temperature is 32° F (0° C) or colder – high inside humidity (40% or greater) combined with l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

w outside temperatures can cause frost to form on the bottom of the roof deck. See Dry Rot in the glossary.

Insulation can trap moisture which will reduce the R-value

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of the insulation and create a nice environment for the propagation of certain molds, spores, and fungi which will also cause problems. See Dry Rot in the glossary.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

There is also the problem of mildew which is both damaging and can cause health problems. The roof system itself will deteriorate prematurely.

Cooling units will ne

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d to be serviced or replaced prematurely because of excessive use. Ice Dams - ice dams are the result of melting snow continually refreezing at the roof perimeter an

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d then backing up under the shingles and causing leaks. Proper ventilation used in conjunction with heavy insulation and an air barrier can create a Cold Roof Assembly

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

which will help eliminate ice dams.

There are many types of attic vents available today. There are static vents, power vents, ridge vents, turbine vents, soffit / co

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nice vents, gable vents, starter vents, and cupola vents. These all come in a wide variety of sizes, styles and shapes. Some will ventilate better than others dependin

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

g on the roof configuration, attic size, climate, etc.

To properly ventilate an attic, two types of vents are needed. Intake vents, which are located at the downslope

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

edge of the roof (a.k.a. eaves) and allow fresh air into the attic; and exhaust vents, which are located near or on the ridge line of the roof and allow air to leave

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

he attic. The use of an exhaust vent in conjunction with an intake vent uses the natural forces of wind pressure and thermal effect, collectively known as the Stack Ef

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

fect, to ventilate the attic space. HINT: Make sure your attic insulation doesn't block the intake vents. If necessary, use baffles to keep the insulation back from it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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References - The Importance of Roof Ventilation

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