References - Home and Family

What a complicated subject this is! First off -it might be helpful to sort out the difference between things that are made to be archival and things that are made to protect things of archival value. For example

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

, the paper you buy on sale at the office supply store to run through your Xerox machine or printer is NOT archival. But an expensive piece of art had better-dang-well-be painted or printed on a piece of paper th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

at you can count on being around for a long time.

On the other side of the coin, there is the stuff you use to protect / store / display valuable stuff. Key word here is "protect." Suppose you carefully tuck yo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ur collectible away in a nice cushy bed of whatever and put it safely away for years and years. Then you take it out -or let's be frank here- your heirs take it out even more years down the road- and find that th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e stuff you so conscientiously used for padding has dissolved into ugly goo and smeared itself all over your item. Your valuable collectible held up perfectly, but is now worthless -or certainly less valuable. T

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

is is actually the topic I want to address in this article, but a few words on archival materials is in order -then I move on-to protecting collectibles with archival SAFE methods.

ARCHIVAL MATERIALS

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Everyone has heard of "acid free" and it sounds like a good thing. Acid is -after all- corrosive -it can burn you and this must be a bad thing. But it turns out that everything is acid. Or alkaline -which is t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

he same thing -only the complete opposite. Your body is acid -slightly. All fruit juice is acidic, carbonated beverages -by virtue of that carbonation over-and-above the fruit juice- is acidic. Vinegar is a goo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

d strong acid -"acetic acid" by name. Lemons make you pucker-up because of citric acid -chemically right next to ascorbic acid -better known as Vitamin C.

So why is acid in certain things bad -and conversely, why

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

is 'acid-free' a good thing? Near as I can tell, things that get manufactured -paper for instance- are easier to manufacture if they have some chemistry done to them. Acid is certainly a sub-set of chemistry.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ou didn't learn about acid in your HS American Literature class did you? My point here is that things that are pretty much the way God made them are safe from self-destruction from the acids they contain. (This

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

is not to say that there are not other ways for them to get messed up -think of it this way. If God made it, He (She?) also made something that eats it.) But wood is probably not going to turn yellow and brittle

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

like a cheap paper-back book. A real butterfly is not apt to curl up and crack like a decorative plastic one. An oil painting (linseed oil & ground mineral pigments on cotton or flax fabric) is not going to fad

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e the way a movie poster does, made with cheap paper and printed with quick drying organic inks.

So what do you do if you have something you value and want to have around for a long time, but you are not sure it'

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s made out of archival materials? Actually, there is not much you can do. Ask questions when you buy it, but does the seller look like they know their chemistry? There is one possibility. There are de-acidifi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ation sprays made to spray on paper (and photographs). Such things go on wet and do chemistry to your collectible. Are you a little hesitant to spray some chemical goo all over a valuable document or image? Don

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

't blame you. One expert -Dennis Smith of Archival Methods says that such things in the hands of a casual user can do more harm then good. If it's this valuable, you would do well to go to a pro who knows the c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hemistry.

But before you even do this -you must ask yourself if you have done all the other things a collector can do to protect his or her collection? Consider my articles on .

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

me-museum.com/How-To-Arts/Preservatioin/Preserv-Contents.htm">Preservation of Collectibles: wherein I address such threats as light & UV, theft, bugs etc., as well as advice on using desiccants and archival-sa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

fe fabrics.

In Part II –Archival Safe METHODS, I take up the issue of the stuff you ought to use to protect your archival valuables. For my entire article with links etc, check out Archival Materials and Methods

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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These days everyone is talking about Elevator Pitches. Are they really all that important? I believe they are, and not just for networking. There's another very important reason to have a clear and concise elevator pitch, and here's why

The new iPod video, which is of a convenient shirt or pocket size, has many options and some of them are absolutely surprising. Apart from the usual options of the iPod – music player, photo viewer, and voice recorder – the new iPod video has several options that may seem revolutionary for some people or useless for others.

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References - Archival Methods and Materials - Part I -Archival Materials

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