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If you have only ever thought of the tin lunch box as a means to carry lunch to school, then

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

prepared to be amazed. The little tin lunch box has not escaped from the attentions of colle

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ctors worldwide. Whenever there are collectors, there is money involved. And when there is

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

money involved, there is potential for business. And so the tin lunch box has become quite a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

good business for serious collectors.

Like normal collectibles, one criteria in determining

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the value of a tin lunch box is the age. The older the tin lunch box, the more valuable it

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

is. Collectors realize that it is very hard to find really old tin lunchboxes in mint condit

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

on because these lunchboxes are actually used as everyday items. Adding to the age then is t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

he condition of the tin lunchbox. Get your hands on a really old tin lunchbox in mint condit

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ion and it could probably pay for your next vacation!

Next in line is the rarity of the lunc

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

h box. If it was mass produced and commonly available, chances are most of the tin lunchbox

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

collectors would own one. This drives the demand of such tin lunchboxes down and drops the v

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

alue as a result. Rare limited edition tin lunchboxes then is the way to go to be a top coll

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ector.

Collectible tin lunchboxes are measured on a rarity scale ranging from 1 to 10 with 1

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

being to rarest. At a rating of 8 to 9 are tin lunchboxes that are very hard to find but no

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t as rare as the 10 rating tin lunchboxes. At the lowest level are tin lunchboxes that are a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

bout 20 years old where finding one in mint condition is a manageable challenge.

So now woul

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d be a good time to head up to the attic or down to the basement to hunt down those tin lunch

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

boxes that you had while you were young. Then you would need to look up the potential value

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

of you tin lunchbox to see if it will pay your bills for a while. Happy tin lunchbox hunting

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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