References - Home and Family

Home-made card balls are attractive and so simple to make. They can be made to any size. Small ones for the Christmas tree or Large ones to decorate a room, they make great alternative to bal

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

loons. You can imagine thrifty Victorians making these card balls to decorate their house at Christmas time.

To begin with you will need a triangle and a circle card board template. You can

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

make these from an old cereal box. The triangle needs to be an equilateral triangle.

You will need cardboard, a pair of compass and a ruler to make your triangle. First draw a straight horiz

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ontal line to form the base of the triangle. Open the compass so that the point and the pencil ate the same distance apart as the length of the ruled line. Then with the pint of the ruler on

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ne end of the ruled line, lightly draw a curve with the compass. The do the same thing with the point of the compass on the other end of the ruled line. Where the two curves cross is the to p

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

oint of the triangle. Rule lines from this point to the base of the triangle. Cut the triangle out and place to one side.

To make the circle template, use the compass to draw a circle a few

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

millimetres larger than the than the triangle.

Now using thin coloured card or old Christmas cards, you need to draw and cut out 20 circles using your template so that they are all the same

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

size. You could use the same coloured card, and then paint the ball once it is complete. You could make a photo ball using photos of all the family stuck to pieces of cardboard.

The circles

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ow need to be folded into shape ready for construction. Lay a card circle face up on the table. Place your triangle template on top and hold it down firmly whilst you fold up the sides of you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

r circle around the triangle template, to form a triangle inside the circle. It's a bit like wrapping up presents. Unwrap the triangle, and move on to the next circle. All 20 circles need tri

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

angle folds fling inside them.

To construct the ball... To attach the folded card circles together simply lift the circle sides on two pieces so that it stands up and forms a ridge, the fol

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ded triangle side butt up to one another. The ridge is where you staple to join the two triangles. Apply more staples for larger balls if you wish to. Staples are also easily removed if you

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ake a mistake.

Join five triangles together so that it forms a dome shape. Make two more domes, each with five triangles joined together. Then join the 3 domes together.

You may find yourse

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lf getting lost at this stage, and you will probably be thinking that it will never work. But it does, just carry on and follow these rules.

Check around your ball. Each triangle has to be p

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

art of a dome where five triangles meet. Add the remaining triangles to the places on your ball where there are too few triangles. Eventually you will have used up all of the triangles and yo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ur ball will be complete.

Tuck some ribbon for hanging between two joining triangles at the point you would like to be the top of the ball.

Finishing touches... You could splatter your bal

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

with coloured paint to create a funky design.

You could apply glue to all the stapled ridges and sprinkle on some glitter to really jazz it up.

You could staple tinsel along the ridges of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a large ball.

You could make a Christmas room decoration centrepiece mobile. Small card balls suspended at varying lengths from one large card ball, with a cut out of Santa hanging from the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

centre.

When your really good at making card balls, substitute staples for glue and make a little gift box for sweets, earrings and other trinkets.

These card balls are brilliant fun. Every

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

one will be amazed at the cleverness of it. Best of all, it's re-cycling at it festive, using old Christmas cards, used cereal boxes, last years odds and ends of gift wrap, tinsel and glitter

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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How do we citizens in the United States of America know that we are over regulated? Well it is pretty obvious when the rest of the world starts laughing at us. But it is even more obvious if you consider all the overregulation in the US on business, in every single industry except one. Lawyers.

Staying in charge of the landlord tenant relationship will create long term tenants. Establishing who's in charge at the beginning and being clear about the rules and expectations will keep problems to a minimum. You are not their friend, this is a business relationship.

Prepaid calling cards can be seen and purchase almost everywhere. Anyone can buy prepaid calling card in many stores including convenience stores and gasoline stations.

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References - Card Decoration Balls - Homemade Christmas Trimmings

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