References - Pets

I would like to share some of my experiences with dogs who are fearful or phobic. First of all there is a difference between fears and phobias. Fears can be worked with and possibly get better but phobias can not be cured they can only be managed.

Phobias often cause dogs

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

to react with irrational behaviors. Canine fears and phobias vein out to feed so many more underlying behavioral issues. Most of the time fears stems from lack of socialization as puppies. Phobias develop from some sort of trauma when the puppy was very young and then t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e fear becomes a learned behavior and finally the fear turns in to a phobia. Traumatic experiences for an adult dog can also instill phobias.

Most common fears are; fears of men, other dogs, loud noises, strange objects, children or it can be anything they were not expose

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

d to as a puppy.

The most common phobias are thunder, fire crackers, car travel and gun shots. The uncommon types of Phobias are other dogs, odors example: veterinary hospitals; then phobias of certain people such as impaired individual’s example: wheel chairs, crutches a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d prosthetic limbs.

The best treatment for these types of behaviors is desensitization. The process is to start applying a very weak stimulus; then gradually increasing the strength. For example a phobia or fear of gun shots would be to desensitize them to the sound by s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

arting the sound off at a distance and gradually approach the dog. You can even play a tape recording of gunshots at a low volume and then graduate to increased loudness. You can find tapes of thunder and other sounds to help desensitize your dog to their fears or phobia

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s.

Another way of desensitizing is counter conditioning. The process for counter conditioning is to ask a dog to do an obedience command for example; a down stay then start the stimuli very weak and reward the dog with food for maintaining the down stay. Only reward the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

og for the desired behavior. If a dog is doing one behavior then they can not do the undesirable behavior at the same time. Increase the stimuli slowly and do consistent exercises to help conquer the fear.

Fears usually develop from lack of socialization as a puppy. If

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

dog is not exposed to different sounds, environments and people it is easy for them to have a fear of the unknown. After your dog is immunized you should do an exercise.

Three called “777”. The exercise is slowly exposing your puppy to a desired object or person. Every

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

thing is paired with positive motivation. Whether it is food or toys or any other thing that is a positive motivator for your dog. You have to introduce your dog to 7 size humans, 7 different surfaces, 7 different environments and 7 sounds at different levels of loudnes

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

.

The first “7” is seven different size humans for example; have a small child just walk pass the puppy at a distance and toss some food at the puppy and walk on. Then again repeat. By the time the child is close enough to meet the puppy it will have paired a child with

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ood things. Pairing the child with food makes the child more desirable.

The second “7” is try to get your puppy on 7 different surfaces. If your puppy is not socialized to sand then at age two when you visit the beach and it steps on this hot sinking surface it may think

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

it is on a different planet and then might exhibit unwanted behavior. If your dog has never gone to the bathroom on anything but grass then if you are in the desert you will have a problem. Besides having a dog get used to different surfaces I also make them eliminate on

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ifferent surfaces [except concrete or any flooring]. The reason for that is a dog should be able to eliminate on bark, pine straw, sand, mud etc. so when you’re traveling your dog will eliminate on whatever surface is around. This will keep you from having to travel with

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ine straw or a square of grass. Some dogs will imprint on one type of surface and only eliminate on that surface.

The third set of “7” is different environments. I take puppies [once fully emmunized] to warehouses, dog parks, soccer games and other environments. If a do

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

g is well-socialized to change and different environments then in the future when they experience these environment it becomes no big deal. When I take my dog or puppy to a new environment I do it slowly. When the dog is comfortable then I will move forward in to the env

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ronment. I pair new places with good treats and then once they are fully comfortable in the environment, I fade the food out and always keep the praise coming.

The fourth “7” is sound desensitization. Puppies and dogs who live inside all the time might build a fear to no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

mal everyday sounds. For example; traffic noises, horns, roller bladers, skate boards etc... To start the process of sound desensitization, I drop a book 2 inches off the floor and toss my dog/puppy a treat. Then I raise the book a little more and repeat till I am droppi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ng the book from 5 feet high. By then the puppy will associate the sound with a reward. This exercise is done slowly and consistently. I raise the level of sounds and add in different sounds. I start with dull noises like books. Then I go to tin sounding noises like dro

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ping cans. I will graduate to a baking sheet which can get quite loud when it is dropped from 5 feet in the air. By the time you get these objects to 5 feet in the air your dog sound be getting socialized to sounds and understand that loud noises produces positive rewards

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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